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KMID : 0381920060360040235
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Korean Journal of Microscopy
2006 Volume.36 No. 4 p.235 ~ p.250
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Protective Effects of Activated Charcoal on the Mouse Hepatotoxicity Induced by Lead
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Cheong Min-Ju
Roh Young-Bok
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Abstract
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A protective effect of activated charcoal against the acute lead poisoning of kidney was studied in mice.Mice approximately 30 gm in weight were grouped into the control, lead acetate-treated, and activated charcoal-treated after lead acetate groups. Lead acetate (60 mg/kg) and activated charcoal (40 mg/kg) were delivered orally. Serum AST, ALT and glucose were measured and the ultrastructural alteration of liver was examined by electron microscopy. Activated charcoal decreased the increase of serum AST, ALT and glucose levels induced by lead. Lead acetate-treated hepatic cells characterized by irregular nuclei, enlarged and reduced number of mitochodria, enlarged rough endoplasmic reticulum, loss of ribosomes. Cells treated with activated charcoal were similar to those of the control group. In Conclusion, activated charcoal may protect the lead-induced toxicity on liver.
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KEYWORD
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Activated charcoal, Liver, Lead, Mouse
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